Epoxomicin

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Chemical Information

Product name：Epoxomicin	Purity：98% min
CAS NO：134381-21-8	Solubility：DMSO : 100 mg/mL (180.27 mM)
Molecular Formula：C₂₈H₅₀N₄O₇	Package：Package according to customer requirements
Molecular Weight：554.719	Storage：Store at -20℃

Quality control

COA

Remarks

Epoxomicin (BU-4061T, Aids010837) is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, while T-L and PGPH catalytic activities are also inhibited at 100- and 1000-fold reduced rate. Epoxomicin promotes apoptosis.

References

[1]. Kim KB, et al. Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3335-40.

[2]. Hanada M, et al. Epoxomicin, a new antitumor agent of microbial origin. J Antibiot (Tokyo). 1992 Nov;45(11):1746-52.

[3]. Garrett IR, et al. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J Clin Invest. 2003 Jun;111(11):1771-82.