GSK583

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Chemical Information

Product name：GSK583	Purity：99% min
CAS NO：1346547-00-9	Solubility：DMSO : ≥ 37 mg/mL (92.86 mM)
Molecular Formula：C₂₀H₁₉FN₄O₂S	Package：Package according to customer requirements
Molecular Weight：398.454	Storage：Store at -20℃

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Remarks

GSK583 is a Highly Potent and Selective Inhibitor of RIP2 Kinase (RIP2K bing IC50=5 nM; rat in vivo PD IC50 = 50 nM). RIP2 kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading to the production of inflammatory cytokines.

References

[1]. Haile PA et al. The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase. J Med Chem, 2016 May 26, 59(10):4867-80.