ONO-4059 analog

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Chemical Information

Product name：ONO-4059 analog	Purity：99.0% min
CAS NO：1351635-67-0	Solubility：DMSO : ≥ 29 mg/mL (63.53 mM)
Molecular Formula：C₂₅H₂₄N₆O₃	Package：Package according to customer requirements
Molecular Weight：456.51	Storage：Store at -20℃

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Remarks

ONO4059-Analog, CAS#1351635-67-0, is a potent and selective BTK inhibitor, and is a structural analogue of ONO-4059. ONO4059 is currently under clinical trials. Note: ONO4059 HCl has CAS#1439901-97-9; ONO4059 free base has CAS#1351636-18-4.

References

[1]. Simon Rule,A Phase I Study Of The Oral Btk Inhibitor ONO-4059 In Patients With Relapsed/Refractory B-Cell Lymphoma. November 15, 2013; Blood: 122 (21)

[2]. Toshio Yoshizawa, et al. Development of a Bruton's Tyrosine Kinase (Btk) Inhibitor, ONO-4059: Efficacy in a Collagen Induced Arthritis (CIA) Model Indicates Potential Treatment for Rheumatoid Arthritis (RA). Washington, DC November 9-14, 2012.