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Product :

RGFP966

RGFP966 1357389-11-7
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Chemical Information
Product name:RGFP966 Purity:98% min
CAS NO:1357389-11-7 Solubility:DMSO : 50 mg/mL (137.97 mM)
Molecular Formula:C21H19FN4O Package:Package according to customer requirements
Molecular Weight:362.400 Storage:Store at -20℃
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Remarks

RGFP966 is a selective HDAC3 inhibitor . S ystemic treatment with RGFP966 facilitates extinction in mice in a manner resistant to reinstatement. A single treatment of RGFP966 enhances extinction of a previously established cocaine-conditioned place preference, while simultaneously enhancing long-term object-location memory within subjects. During extinction consolidation, HDAC3 inhibition promotes a distinct pattern of histone acetylation linked to gene expression within the infralimbic cortex, hippocampus, and nucleus accumbens. Thus, the facilitated extinction of drug-seeking cannot be explained by adverse effects on performance.


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