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GNE-617

GNE-617 1362154-70-8
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Chemical Information
Product name：GNE-617 Purity：98% min
CAS NO：1362154-70-8 Solubility：DMSO : ≥ 42.85 mg/mL (100.25 mM)
Molecular Formula：C21H15F2N3O3S Package：Package according to customer requirements
Molecular Weight：427.424 Storage：Store at -20℃
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Remarks
GNE-617 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with IC50 value of 5nM. Prolonged inhibition of nicotinamide phosphoribosyltransferase (NAMPT) is a strategy for targeting cancer metabolism.
References

[1]. Shames DS, et al. Loss of NAPRT1 Expression by Tumor-specific Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors. Clin Cancer Res. 2013 Dec 15;19(24):6912-23.

[2]. Zabka TS, et al. Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase. Toxicol Sci. 2015 Mar;144(1):163-72.

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