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RP 70676

RP 70676 136609-26-2
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Chemical Information
Product name:RP 70676 Purity:98% min
CAS NO:136609-26-2 Solubility:Soluble in DMSO
Molecular Formula:C25H28N4S Package:Package according to customer requirements.
Molecular Weight:416.58 Storage:Store at -20℃
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RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC50 = 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC50 is 44 nM. In whole cell P388D, murine macrophages the compound has an IC50 of 540 nM.






[1]. M.J. Ashton, et al. RP 70676: A potent systematically available inhibitor of acyl-CoA:cholesterol O-acyl transferase (ACAT). Bioorganic & Medicinal Chemistry Letters Volume 2, Issue 5, 1992, Pages 375-380.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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