E-2006 Lemborexant

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Chemical Information

Product name：E-2006 Lemborexant	Purity：98.0% min
CAS NO：1369764-02-2	Solubility：DMSO : ≥ 30 mg/mL (73.10 mM)
Molecular Formula：C₂₂H₂₀F₂N₄O₂	Package：Package according to customer requirements
Molecular Weight：410.417	Storage：Store at -20℃

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Remarks

Lemborexant, also known as E-2006, is a dual antagonist of the orexin OX1 and OX2 receptors which is under development by Eisai for the treatment of insomnia. As of December 2014, it is in phase II clinical trials.

Chemical Name:
(1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide

References

[1]. OREXIN RECEPTOR ANTAGONIST PROVEN EFFECTIVE FOR BOTH SLEEP ONSET AND SLEEP MAINTENANCE IN CLINICAL DEVELOPMENT PROGRAM OF MORE THAN 2,000 PATIENTS. 2019.

[2]. HIGHLIGHTS OF PRESCRIBING INFORMATION/