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GSK-J4 HCl

GSK-J4 HCl 1373423-53-0
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Chemical Information
Product name:GSK-J4 HCl Purity:98% min
CAS NO:1373423-53-0 Solubility:DMSO : ≥ 36 mg/mL (86.23 mM)
Molecular Formula:C24H27N5O2 Package:Package according to customer requirements
Molecular Weight:417.503 Storage:Store at -20℃
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Remarks
GSK-J4 is a cell permeable, potent and selective histone demethylase. GSK-J4 is a prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family. GSK-J4 is used to probe the consequences of demethylation of H3K27me3. GSK-J4 inhibits the lipopolysaccharide-induced production of cytokines, including pro-inflammatory tumour necrosis factor (TNF).
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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