Product :
DM1-Sme Mertansine
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Chemical Information
| Product name：DM1-Sme Mertansine |
Purity：99.0% min |
| CAS NO：138148-68-2 |
Solubility： |
| Molecular Formula：C36H50ClN3O10S2 |
Package：Package according to customer requirements |
| Molecular Weight：784.379 |
Storage：Store at -20℃ |
Remarks
DM1-SMe is a potent maytansinoid microtubular inhibitor and an unconjugated DM1 as a mixed disulfide with thiomethane to cap its sulfhydryl group. DM1-SMe can be readily conjugate to the SH group of an antibody to form antibody-drug conjugate (ADC).
References
1: Wood AC, Maris JM, Gorlick R, Kolb EA, Keir ST, Reynolds CP, Kang MH, Wu J, Kurmasheva RT, Whiteman K, Houghton PJ, Smith MA. Initial testing (Stage 1) of the antibody-maytansinoid conjugate, IMGN901 (Lorvotuzumab mertansine), by the pediatric preclinical testing program. Pediatr Blood Cancer. 2013 Nov;60(11):1860-7. doi: 10.1002/pbc.24647. Epub 2013 Jun 24. PubMed PMID: 23798344; PubMed Central PMCID: PMC4260400.