Brinzolamide

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Chemical Information

Product name：Brinzolamide	Purity：98% min
CAS NO：138890-62-7	Solubility：DMSO : 100 mg/mL (260.75 mM)
Molecular Formula：C₁₂H₂₁N₃O₅S₃	Package：Package according to customer requirements
Molecular Weight：383.507	Storage：-20℃

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Remarks

Brinzolamide is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion and thus lowers the intraocular pressure in the anterior chamber, presumably by reducing the rate of formation of bicarbonate ions with subsequent reduction in sodium and fluid transport; this alleviates the effects of open-angle glaucoma.

References

[1]. DeSantis, L., Preclinical overview of brinzolamide. Surv Ophthalmol, 2000. 44 Suppl 2: p. S119-29.

[2]. Silver, L.H., Dose-response evaluation of the ocular hypotensive effect of brinzolamide ophthalmic suspension (Azopt). Brinzolamide Dose-Response Study Group. Surv Ophthalmol, 2000. 44 Suppl 2: p. S147-53.