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LYS01

LYS01 1391426-22-4
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Chemical Information
Product name:LYS01 Purity:99% min
CAS NO:1391426-22-4 Solubility:Insuluble (8.4E-5 g/L) (25 ºC)
Molecular Formula:C23H23Cl2N5 Package:Package according to customer requirements
Molecular Weight:440.368 Storage:Store at -20℃
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Remarks
LYS01 free base is a new lysosomal autophagy inhibitor. Lys01 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. The trihydydrochloride salt of LYS01 is called LYS05. Lys05, a water-soluble salt of Lys01, more potently accumulates within and deacidifies the lysosome, resulting in impaired autophagy and tumor growth.
References

1: Amaravadi RK, Winkler JD. Lys05: a new lysosomal autophagy inhibitor. 
Autophagy. 2012 Sep;8(9):1383-4. doi: 10.4161/auto.20958. PubMed PMID: 22878685; 
PubMed Central PMCID: PMC3442884.

2: McAfee Q, Zhang Z, Samanta A, Levi SM, Ma XH, Piao S, Lynch JP, Uehara T, 
Sepulveda AR, Davis LE, Winkler JD, Amaravadi RK. Autophagy inhibitor Lys05 has 
single-agent antitumor activity and reproduces the phenotype of a genetic 
autophagy deficiency. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8253-8. doi: 
10.1073/pnas.1118193109. PubMed PMID: 22566612; PubMed Central PMCID: PMC3361415.


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