PF-06291874

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Chemical Information

Product name：PF-06291874	Purity：98% min
CAS NO：1393124-08-7	Solubility：DMSO : ≥ 30 mg/mL (59.58 mM)
Molecular Formula：C₂₆H₂₈F₃N₃O₄	Package：Package according to customer requirements
Molecular Weight：503.513	Storage：Store at -20℃

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Remarks

PF-06291874 is a glucagon receptor antagonist nd potentially usefully for patients with type 2 diabetes mellitus. PF-06291874 was well tolerated, has a pharmacokinetic profile suitable for once-daily dosing, and results in reductions in glucose with minimal risk of hypoglycaemia.

References

[1]. Guzman-Perez A et al. The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical andpharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus. Bioorg Med Chem Lett, 2013 May 15, 23(10):3051-8.

[2]. Esther C.Y. Lee et al. Identification of a novel conformationally constrained glucagon receptor antagonist. Bioorg Med Chem Lett, 2014 Feb 1, 24(3):839-44.