ML277

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Chemical Information

Product name：ML277	Purity：98% min
CAS NO：1401242-74-7	Solubility：DMSO : ≥ 56 mg/mL (118.75 mM)
Molecular Formula：C₂₃H₂₅N₃O₄S₂	Package：Package according to customer requirements
Molecular Weight：471.592	Storage：Store at 2-8°C

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Remarks

ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM. IC50 value: 270 nM (EC50) [1] Target: K(v)7.1 activator ML277 was shown to be highly selective against other KCNQ channels (>100-fold selectivity versus KCNQ2 and KCNQ4) as well as against the distantly related hERG potassium channel.

References

[1]. Mattmann ME, et al. Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5936-41.