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TMP778

TMP778 1422171-08-1
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Chemical Information
Product name:TMP778 Purity:98% min
CAS NO:1422171-08-1 Solubility:
Molecular Formula:C31H30N2O4 Package:Package according to customer requirements
Molecular Weight:494.581 Storage:-20 ℃
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Remarks

TMP778 is a potent and selective RORγt inhibitor that suppresses experimental autoimmune uveitis development, but affects both Th17 and Th1 cell populations.

References
[1]. Skepner J, et al. Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo. J Immunol. 2014 Mar 15;192(6):2564-75. [2]. Xiao S, et al. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity. 2014 Apr 17;40(4):477-89.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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