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ND-630

ND-630 1434635-54-7
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Chemical Information
Product name:ND-630 Purity:98%min
CAS NO:1434635-54-7 Solubility:Soluble in DMSO
Molecular Formula:C28H31N3O8S Package:Packaging according to customer requirements
Molecular Weight:569.63 Storage:Store at -20℃
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Remarks
ND-630 is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC50 values of 2.1 and 6.1 nM, respectively.ND-630 inhibits hACC1 (IC50=2.1±0.2 nM) and hACC2 (IC50=6.1±0.8 nM). Inhibition is reversible and highly specific for ACC. ND-630 inhibits ACC activity by interacting within the phosphopeptide-acceptor and dimerization site of the enzyme to prevent dimerization. ND-630 inhibits fatty acid synthesis with an EC50 of 66 nM in HepG2 cells without altering the total cell number, cellular protein concentration, and incorporation of acetate into cholesterol[1].
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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