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ND-630 NDI-010976

ND-630 NDI-010976 1434635-54-7
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Chemical Information
Product name:ND-630 NDI-010976 Purity:98% min
CAS NO:1434635-54-7 Solubility:Soluble in DMSO
Molecular Formula:C28H31N3O8S Package:Package according to customer requirements
Molecular Weight:569.629 Storage:Store at -20℃
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Remarks
ND-630, also known as GS-0976, NDI-010976, and firsocostat, is a potent ACC inhibitor. ND-630 nteracts within the ACC phosphopeptide acceptor and dimerization site to prevent dimerization and inhibit the enzymatic activity of both ACC isozymes, reduce fatty acid synthesis and stimulate fatty acid oxidation in cultured cells and in animals, and exhibit favorable drug-like properties. ND-630 reduces hepatic steatosis, improves insulin sensitivity, reduces weight gain without affecting food intake, and favorably affects dyslipidemia. When administered chronically to Zucker diabetic fatty rats, ND-630 reduces hepatic steatosis, improves glucose-stimulated insulin secretion, and reduces hemoglobin A1c (0.9% reduction).
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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