A 419259 trihydrochloride

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Chemical Information

Product name：A 419259 trihydrochloride	Purity：98% min
CAS NO：1435934-25-0	Solubility：H2O : ≥ 55 mg/mL (92.91 mM)
Molecular Formula：C₂₉H₃₇Cl₃N₆O	Package：Package according to customer requirements
Molecular Weight：592.003	Storage：Store at -20℃

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Remarks

A 419259 trihydrochloride is a Src family kinases inhibitor with IC₅₀s of 9 nM, 3 nM and 3 nM for Src, Lck and Lyn, respectively.

References

[1]. Wilson MB, et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002 Nov 21;21(53):8075-88.

[2]. Pene-Dumitrescu T, et al. An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259.Oncogene (2008) 27, 7055-7069