Triapine

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Chemical Information

Product name：Triapine	Purity：99% min
CAS NO：143621-35-6	Solubility：DMSO : ≥ 47 mg/mL (240.73 mM)
Molecular Formula：C₇H₉N₅S	Package：Package according to customer requirements
Molecular Weight：195.245	Storage：-20℃

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Remarks

Triapine, also known as 3-AP and OCX-191, is a synthetic heterocyclic carboxaldehyde thiosemicarbazone with potential antineoplastic activity. Triapine inhibits the enzyme ribonucleotide reductase, resulting in the inhibition of the conversion of ribonucleoside diphosphates to deoxyribonucleotides necessary for DNA synthesis. This agent has been shown to inhibit tumor growth in vitro.

Properties:
Density: 1.46g/cm3
Boiling Point: 436ºC at 760mmHg
Flash Point: 217.5ºC

References

[1]. Martin LK, et al. A dose escalation and pharmacodynamic study of Triapine and radiation in patients with locally advanced pancreas cancer. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e475-81.

[2]. Yalowich JC, et al. The anticancer thiosemicarbazones Dp44mT and Triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα. Biochem Pharmacol. 2012 Jul 1;84(1):52-8.