Product :
GBT440 Voxelotor
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Chemical Information
Product name:GBT440 Voxelotor |
Purity:98% min |
CAS NO:1446321-46-5 |
Solubility:DMSO : ≥ 125 mg/mL (370.51 mM) |
Molecular Formula:C19H19N3O3 |
Package:Package according to customer requirements |
Molecular Weight:337.3720 |
Storage:Store at -20℃ |
Remarks
Voxelotor, also known as GBT-440, is a hemoglobin S allosteric modulator. GBT440 Inhibits Sickling of Sickle Cell Trait Blood Under In Vitro Conditions Mimicking Strenuous Exercise. GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease. GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease