Product :
K145 hydrochloride
Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.
Chemical Information
Product name:K145 hydrochloride |
Purity:98% min |
CAS NO:1449240-68-9 |
Solubility:DMSO : 50 mg/mL (129.90 mM) |
Molecular Formula:C18H25ClN2O3S |
Package:Package according to customer requirements |
Molecular Weight:384.921 |
Storage:Store at 2-8°C |
Remarks
K145 is a selective sphingosine kinase-2 (SphK2) inhibitor and anticancer agent. K145 inhibited the activity of SphK2 in a dose-dependent manner with an IC50 of 4.30±0.06 µM. K145 also exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells. K145 exhibits comparable in vivo anti-tumor activity to tamibarotene, while concomitantly exhibiting less toxicity in this U937 xenograft cancer model.