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|Product name：K145 hydrochloride
||Solubility：DMSO : 50 mg/mL (129.90 mM)
||Package：Package according to customer requirements
||Storage：Store at -20℃
K145 is a selective sphingosine kinase-2 (SphK2) inhibitor and anticancer agent. K145 inhibited the activity of SphK2 in a dose-dependent manner with an IC50 of 4.30Â±0.06 ÂµM. K145 also exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells. K145 exhibits comparable in vivo anti-tumor activity to tamibarotene, while concomitantly exhibiting less toxicity in this U937 xenograft cancer model.