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K145 hydrochloride

K145 hydrochloride 1449240-68-9
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Chemical Information
Product name:K145 hydrochloride Purity:98% min
CAS NO:1449240-68-9 Solubility:DMSO : 50 mg/mL (129.90 mM)
Molecular Formula:C18H25ClN2O3S Package:Package according to customer requirements
Molecular Weight:384.921 Storage:Store at -20℃
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K145 is a selective sphingosine kinase-2 (SphK2) inhibitor and anticancer agent. K145 inhibited the activity of SphK2 in a dose-dependent manner with an IC50 of 4.30±0.06 µM. K145 also exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells. K145 exhibits comparable in vivo anti-tumor activity to tamibarotene, while concomitantly exhibiting less toxicity in this U937 xenograft cancer model.
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