DDR1-IN-1

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Chemical Information

Product name：DDR1-IN-1	Purity：99% min
CAS NO：1449685-96-4	Solubility：DMSO : 100 mg/mL (180.97 mM); H2O : < 0.1 mg/mL
Molecular Formula：C₃₀H₃₁F₃N₄O₃	Package：Package according to customer requirements
Molecular Weight：552.587	Storage：Store at -20℃

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Remarks

DDR1-IN-1 is a potent and selective DDR1 inhibitor with IC50 of 105 nM, about 3-fold selectivity over DDR2. DDR1-IN-1 binds to DDR1 in the 'DFG-out' conformation and inhibits DDR1 autophosphorylation in cells at submicromolar concentrations with good selectivity as assessed against a panel of 451 kinases measured. DDR1-IN-1 provides a useful pharmacological probe for DDR1-dependent signal transduction. The DDR1 receptor tyrosine kinase is activated by matrix collagens and has been implicated in numerous cellular functions such as proliferation, differentiation, adhesion, migration, and invasion.

References

[1]. Kim HG, et al. Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS Chem Biol. 2013 Oct 18;8(10):2145-50.