Leucovorin calcium hydrate

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Chemical Information

Product name：Leucovorin calcium hydrate	Purity：99% min
CAS NO：1492-18-8	Solubility：H2O : ≥ 200 mg/mL (391.01 mM)
Molecular Formula：C₂₀H₂₁CaN₇O₇	Package：Package according to customer requirements
Molecular Weight：C20H21CaN7O7	Storage：Store at -20℃

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Remarks

Folinic Acid Calcium Salt is a derivative of Folic Acid , a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate. Has been shown to be partially effective in the treatment children suffering from autism spectrum disorders (ASDs).

Properties
Appearance & Physical State: yellow crystalline powder
Melting Point: 240-250ºC
Stability: Stable at normal temperatures in tightly closed containers under an inert atmosphere.
Storage Condition: Store in a tightly closed container. Keep under an argon blanket. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4ºC). Store protected from light and air.

References

[1]. Schilsky RL, Ratain MJ. Clinical pharmacokinetics of high-dose leucovorin calcium after intravenous and oral administration. J Natl Cancer Inst. 1990 Sep 5;82(17):1411-5.

[2]. Chang WN, Tsai JN, Chen BH, Serine hydroxymethyltransferase isoforms are differentially inhibited by leucovorin: characterization and comparison of recombinant zebrafish serine hydroxymethyltransferases. Drug Metab Dispos. 2007 Nov;35(11):2127-37.