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EMA400

EMA400 152362-51-1
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Chemical Information
Product name:EMA400 Purity:98% min
CAS NO:152362-51-1 Solubility:Soluble in DMSO
Molecular Formula:C32H29NO5 Package:Package according to customer requirements
Molecular Weight:507.576 Storage:Store at -20℃
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Remarks
EMA400 is a potent and highly selective AT2R antagonist. The angiotensin II type 2 (AT2) receptor is a target with promising data in rodent models of peripheral neuropathic pain.
References

1: Anand U, Yiangou Y, Sinisi M, Fox M, MacQuillan A, Quick T, Korchev YE, Bountra C, McCarthy T, Anand P. Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies. Mol Pain. 2015 Jun 26;11:38. doi: 10.1186/s12990-015-0038-x. PubMed PMID: 26111701; PubMed Central PMCID: PMC4482278.

2: Rice AS, Smith MT. Angiotensin II type 2-receptor: new clinically validated target in the treatment of neuropathic pain. Clin Pharmacol Ther. 2015 Feb;97(2):128-30. doi: 10.1002/cpt.29. Epub 2014 Dec 20. PubMed PMID: 25670516.

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