Pleconaril Picovir

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Chemical Information

Product name：Pleconaril Picovir	Purity：98% min
CAS NO：153168-05-9	Solubility：DMSO : 100 mg/mL (262.23 mM)
Molecular Formula：C₁₈H₁₈F₃N₃O₃	Package：Package according to customer requirements
Molecular Weight：381.349	Storage：Store at -20℃

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Remarks

Pleconaril is an antiviral drug potentially for the treatment of enterovirus infection and asthma. Pleconaril, administered either orally or intranasally, is active against viruses in the Picornaviridae family, including Enterovirus and Rhinovirus.It has shown useful activity against the dangerous strain enterovirus D68. Pleconaril binds to a hydrophobic pocket in the VP1 protein. Pleconaril has been shown in viral assembly to associate with viral particles.[9] Through noncovalent, hydrophobic interactions compounds can bind to the hydrophobic pocket. Amino acids in positions Tyr152 and Val191 are a part of the VP1 drug binding pocket.

Properties:
Density: 1.271
Boiling Point: 481.2ºC at 760mmHg
Flash Point: 244.8ºC
Refractive Index: 1.509
Vapor Pressure: 5.94E-09mmHg at 25°C

References

[1]. Benschop KS, et al. Genetic and antigenic structural characterization for resistance of echovirus 11 to pleconaril in an immunocompromised patient. J Gen Virol. 2015 Mar;96(Pt 3):571-9.

[2]. Lacroix C, et al. http://www.ncbi.nlm. In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses. Virol J. 2015 Jul 14;12:106.