ML355

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Chemical Information

Product name：ML355	Purity：98% min
CAS NO：1532593-30-8	Solubility：DMSO : ≥ 42 mg/mL (95.13 mM)
Molecular Formula：C₂₁H₁₉N₃O₄S₂	Package：Package according to customer requirements
Molecular Weight：441.523	Storage：DMSO : ≥ 42 mg/mL (95.13 mM)

Quality control

COA

Remarks

ML355 is a potent and selective inhibitors of 12-Lipoxygenase(12-LOX) with IC50 of 0.34 μM, excellent selectivity over related lipoxygenases and cyclooxygenases, and possess favorable ADME properties. IC50 value: 0.34 μM [1] Target: 12-LOX ML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells.

References

[1]. Luci DK, et al. Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem. 2014 Jan 23;57(2):495-506.

[2]. Zhang XJ, et al. An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury. Nat Med. 2018 Jan;24(1):73-83.