Cevimeline hydrochloride hemihydrate

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：Cevimeline hydrochloride hemihydrate	Purity：98% min
CAS NO：153504-70-2	Solubility：H2O : ≥ 50 mg/mL (114.92 mM)
Molecular Formula：C₂₀H₃₈Cl₂N₂O₃S₂	Package：Package according to customer requirements
Molecular Weight：489.563	Storage：Store at -20℃

Quality control

Remarks

Cevimeline hydrochloride hemihydrate, a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.
IC50 value:
Target: mAChR

Properties:
Density: 1.19g/cm3
Boiling Point: 308.5ºC at 760mmHg
Flash Point: 140.4ºC
Vapor Pressure: 0.000676mmHg at 25°C

References

[1]. Iga Y, Arisawa H, Ogane N, Saito Y, Tomizuka T, Nakagawa-Yagi Y, Masunaga H, Yasuda H, Miyata N. (+/-)-cis-2-methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride, hemihydrate (SNI-2011, cevimeline hydrochloride) induces saliva and tear secretions

[2]. Omori Y, Asari T, Maruyama K, Kusama H, Kojima M, Shibata N. Effects of pilocarpine hydrochloride and cevimeline on submandibular/sublingual salivation in rat xerostomia model produced by X-ray irradiation. Arzneimittelforschung. 2003;53(5):342-50.