PST-2238 Rostafuroxin

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Chemical Information

Product name：PST-2238 Rostafuroxin	Purity：98% min
CAS NO：156722-18-8	Solubility：DMSO : ≥ 50 mg/mL (133.51 mM)
Molecular Formula：C₂₃H₃₄O₄	Package：Package according to customer requirements
Molecular Weight：374.514	Storage：Store at -20℃

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Remarks

Rostafuroxin, also known as PST-2238, is an ouabain antagonist. Rostafuroxin protects from podocyte injury and proteinuria induced by adducin genetic variants and ouabain. Rostafuroxin ameliorates endothelial dysfunction and oxidative stress in resistance arteries from deoxycorticosterone acetate-salt hypertensive rats: the role of Na+K+-ATPase/ cSRC pathway. Rostafuroxin corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension.

References

[1]. Quadri L, et al. 17 beta-(3-furyl)-5 beta-androstane-3 beta, 14 beta, 17 alpha-triol (PST 2238). A very potent antihypertensive agent with a novel mechanism of action. J Med Chem. 1997 May 23;40(11):1561-4.

[2]. Ferrari P, et al. PST 2238: A new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension. J Pharmacol Exp Ther. 1999 Mar;288(3):1074-83.

[3]. Ferrari P, et al. Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension. Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R529-35.