Product :
INH154
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Chemical Information
Product name:INH154 |
Purity:98% min |
CAS NO:1587705-63-2 |
Solubility:DMSO : 62.5 mg/mL (159.23 mM) |
Molecular Formula:C22H24N4OS |
Package:Package according to customer requirements |
Molecular Weight:392.521 |
Storage:Store at -20℃ |
Remarks
INH154 is a novel small molecules disrupting Hec1/Nek2 interaction, inhibits HeLa and MDA-MB-468 cancer cells growth with IC50 of 0.20 and 0.12 uM, respectively; suppresses the growth of leukemia, osteosarcoma, and glioblastoma cells, but has no significant growth inhibitory effects on non-tumorigenic fibroblast, HS27 and mammary epithelial cells; triggers Nek2 degradation and eventually cell death, suppresses tumor growth in mice without obvious toxicity.
References
1. Hu CM, et al. Oncogene. 2015 Mar 5;34(10):1220-30.