GSK-843

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Chemical Information

Product name：GSK-843	Purity：98% min
CAS NO：1601496-05-2	Solubility：
Molecular Formula：C₁₉H₁₅N₅S₂	Package：Package according to customer requirements
Molecular Weight：377.49	Storage：-20℃

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Remarks

GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM[1]. IC50: 6.5 nM (RIP3)[1]

References

[1]. Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95.