TX1-85-1

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Chemical Information

Product name：TX1-85-1	Purity：98% min
CAS NO：1603845-32-4	Solubility：DMSO : 3.85 mg/mL (6.63 mM)
Molecular Formula：C₃₂H₃₆N₈O₃	Package：Package according to customer requirements
Molecular Weight：580.68	Storage：-20 ℃

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Remarks

TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling.

References

[1]. Xie T, et al. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec;10(12):1006-12.