Deucravacitinib (BMS-986165)

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Chemical Information

Product name：Deucravacitinib (BMS-986165)	Purity：98% min
CAS NO：1609392-27-9	Solubility：In DMSO
Molecular Formula：C₂₀H₁₉D₃N₈O₃	Package：Package according to customer requirements.
Molecular Weight：425.47	Storage：Store at -20℃

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Remarks

Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases, which selectively binds to TYK2 pseudokinase (JH2) domain (IC₅₀=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain. Deucravacitinib inhibits IL-12/23 and type I IFN pathways

References

[1]. Wrobleski ST, et al. Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J Med Chem. 2019 Jul 18.

[2]. Catlett I, et al. SAT0226 A first-in-human, study of BMS-986165, a selective, potent, allosteric small molecule inhibitor of tyrosine kinase 2. Annals of the Rheumatic Diseases 2017;76:859.