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vincamine

vincamine 1617-90-9
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Chemical Information
Product name:vincamine Purity:98% min
CAS NO:1617-90-9 Solubility:DMSO : ≥ 38 mg/mL (107.21 mM)
Molecular Formula:C21H26N2O3 Package:Package according to customer requirements
Molecular Weight:354.443 Storage:Store at -20℃
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Remarks
Vincamine is a poorly soluble potent neuroprotector and cerebral vasodilator, used for the treatment for CNS disorders. In some cases, the bioavailability of pure compounds is strongly influenced by the co-administration of other constituents, and in some cases, the so called 'phytocomplex' may act as enhancer of absorption of selected phytochemicals.
References

1: Hasa D, Perissutti B, Dall'Acqua S, Chierotti MR, Gobetto R, Grabnar I, Cepek C, Voinovich D. Rationale of using Vinca minor Linne dry extract phytocomplex as a vincamine's oral bioavailability enhancer. Eur J Pharm Biopharm. 2013 May;84(1):138-44. doi: 10.1016/j.ejpb.2012.11.025. Epub 2012 Dec 11. PubMed PMID: 23238273.

2: Mayo BC, Biggs SR, Hawkins DR, Chasseaud LF, Darragh A, Leaf FC. The metabolic fate of 11-bromo[15-3H]vincamine in man. Eur J Drug Metab Pharmacokinet. 1985 Jul-Sep;10(3):189-96. PubMed PMID: 4085521.

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