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AZD8186

AZD8186 1627494-13-6
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Chemical Information
Product name:AZD8186 Purity:99% min
CAS NO:1627494-13-6 Solubility:DMSO : ≥ 35 mg/mL (76.51 mM)
Molecular Formula:C24H25F2N3O4 Package:Package according to customer requirements
Molecular Weight:457.470 Storage:Store at -20℃
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Remarks
AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. Upon administration, PI3Kbeta inhibitor AZD8186 selectively inhibits the activity of PI3Kbeta in the PI3K/Akt/mTOR signaling pathway, which may result in a decrease of tumor cell proliferation. It also induces cell death in PI3K-expressing cancer cells. By specifically targeting class I PI3K beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors. PI3K-mediated signaling is often dysregulated in cancer cells and contributes to increased tumor cell growth, survival, and tumor resistance to a variety of antineoplastic agents. AZD8186 is currently under Phase I clinical trials.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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