Product :
PFI-2
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Chemical Information
| Product name：PFI-2 |
Purity：98% min |
| CAS NO：1627676-59-8 |
Solubility：10 mM in DMSO |
| Molecular Formula：C23H25F4N3O3S |
Package：Package according to customer requirements |
| Molecular Weight：499.522 |
Storage：Store at -20℃ |
Remarks
PFI-2 is a potent inhibitor of SETD7 with IC50 2 nM and 1000-fold selectivity over other methyltransferases and other non-epigenetic targets. PFI-2 has been shown to bind to SETD7 by ITC (Kd=18nM) and biotinylated PFI-2 interacts with SETD7 in pull-down studies. Its enantiomer (S)-PFI-2 is 500-fold less active making it an excellent negative control. Treatment of low-density MEFs with (R)-PFI-2 resulted in higher nuclear YAP levels indicating an effect on the Hippo pathway.