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Product :

MI-463

MI-463 1628317-18-9
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Chemical Information
Product name:MI-463 Purity:98% min
CAS NO:1628317-18-9 Solubility:DMSO : 125 mg/mL (257.98 mM)
Molecular Formula:C24H23F3N6S Package:Package according to customer requirements.
Molecular Weight:484.54 Storage:Store at -20℃
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Remarks

MI-463 is a potent menin-MLL inhibitor with IC50=15.3 nM and Kd=9.9 nM. MI-463 shows its profound effects in MLL leukemia cells and substantial survival benefit in mouse models of MLL leukemia. Pharmacologic inhibition of the menin-MLL interaction represents an effective treatment for MLL leukemias in vivo and provide advanced molecular scaffold for clinical lead identification. Chromosomal translocations affecting mixed lineage leukemia gene (MLL) result in acute leukemias resistant to therapy. The leukemogenic activity of MLL fusion proteins is dependent on their interaction with menin, providing basis for therapeutic intervention.

 

Properties:

Boiling point: 663.2±55.0 °C(Predicted)

density: 1.43±0.1 g/cm3(Predicted)

pka: 14.56±0.30(Predicted)

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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