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Product :

AF64394

AF64394  1637300-25-4
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Chemical Information
Product name:AF64394 Purity:98% min
CAS NO:1637300-25-4 Solubility:DMSO : ≥ 125 mg/mL (317.36 mM)
Molecular Formula:C21H20ClN5O Package:Package according to customer requirements
Molecular Weight:393.87 Storage:-20℃
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COA
Remarks

AF64394 is a selective GPR3 Inverse Agonist. It is the first small molecule inhibitor of GPR3 receptor function.

AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3. AF34394 and related compounds are only of modest potency and are relatively lipophilic (e.g., AF34394 clogP=5.2, LLE=2.1, and 14b clog P=3.1 and LLE=3.2) the series shows promising SAR and represents an excellent start point for further optimization.

 

Synonyms:

[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine, N-[[4-chloro-2-(1-methylethoxy)phenyl]methyl]-5-phenyl-;

N-[[4-Chloro-2-(1-methylethoxy)phenyl]methyl]-5-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine;

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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