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Product :

GSK484 HCl

GSK484 HCl 1652591-81-5
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Chemical Information
Product name：GSK484 HCl Purity：98% min
CAS NO：1652591-81-5 Solubility：DMSO : 62.5 mg/mL (122.54 mM)
Molecular Formula：C28H35N5O3 Package：Package according to customer requirements
Molecular Weight：489.609 Storage：-20 ℃
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Remarks

GSK484 HCl, a benzoimidazole derivative, is a selective and reversible inhibitor of peptidylarginine deiminase 4 (PAD4) with IC50 of 50 nM in the absence of Calcium.

References

[1]. Lewis HD, et al. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat Chem Biol. 2015 Mar;11(3):189-91.

[2]. Cedervall J, et al. Pharmacological targeting of peptidylarginine deiminase 4 prevents cancer-associated kidney injury in mice. Oncoimmunology. 2017 Apr 20;6(8):e1320009.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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