BMS453

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Chemical Information

Product name：BMS453	Purity：98% min
CAS NO：166977-43-1	Solubility：
Molecular Formula：C₂₇H₂₄O₂	Package：Package according to customer requirements
Molecular Weight：380.478	Storage：-20℃

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Remarks

BMS453 is a retinoic acid receptor β (RARβ) agonist in vivo and also RARα and RARγ antagonist in vitro. BMS453 inhibits breast cell proliferation by inducing active transforming growth factor β (TGFβ) and causes G1 arrest.

References

[1]. J Y Chen, et al. RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation. EMBO J. 1995 Mar 15;14(6):1187-97.

[2]. L Yang, et al. The retinoic acid receptor antagonist, BMS453, inhibits normal breast cell growth by inducing active TGFbeta and causing cell cycle arrest. Oncogene. 2001 Nov 29;20(55):8025-35.