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CD38 inhibitor 78c

CD38 inhibitor 78c 1700637-55-3
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Chemical Information
Product name:CD38 inhibitor 78c Purity:98.0% min
CAS NO:1700637-55-3 Solubility:DMSO : 35.71 mg/mL (86.35 mM; Need ultrasonic)
Molecular Formula:C22H27N3O3S Package:Package according to customer requirements
Molecular Weight:413.533 Storage:Store at -20℃
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Remarks

CD38 inhibitor 1 (compound 78c, CD38-IN-78c, MDK-7553) is a potent inhibitor of CD38 with IC50 of 7.3 nM and 1.9 nM for human CD38 and mouse CD38, respetively.

 

In vitro:

CD38 inhibitor 1 (compound 78c) increases NAD+ levels, resulting in activation of pro-longevity and health span-related factors including sirtuins, AMPK, and PARPs.

 

In vivo:

CD38 inhibitor 1 (compound 78c) is found to not only be a very potent inhibitor, but also had suitable physiochemical properties to serve as a robust tool for in vivo studies. In addition, CD38 inhibitor 1 (compound 78c) is able to elevate NAD in both liver and gastrocnemius tissue when dosed orally in a DIO mouse.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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