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Nepicastat hydrochloride

Nepicastat hydrochloride 170151-24-3
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Chemical Information
Product name:Nepicastat hydrochloride Purity:98% min
CAS NO:170151-24-3 Solubility:DMSO : 6 mg/mL (18.08 mM)
Molecular Formula:C14H16ClF2N3S Package:Package according to customer requirements
Molecular Weight:331.812 Storage:Store at -20℃
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Remarks

Nepicastat, also known as SYN117 and RS-25560-197, is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine. It has been studied as a possible treatment for congestive heart failure, and appears to be well tolerated. As of 2012, clinical trials to assess nepicastat as a treatment for post-traumatic stress disorder (PTSD) and cocaine dependence have been completed. In Phase 2 study treatment with nepicastat was not effective in relieving PTSD-associated symptoms when compared to placebo.

Nepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2.

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