HMN-214

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Chemical Information

Product name：HMN-214	Purity：98% min
CAS NO：173529-46-9	Solubility：10 mM in DMSO
Molecular Formula：C₂₂H₂₀N₂O₅S	Package：Package according to customer requirements
Molecular Weight：424.470	Storage：Store at -20℃

Quality control

Remarks

HMN-214 is an oral prodrug of HMN-176, a stilbene derivative that interferes with the subcellular spatial location of polo-like kinase-1, a serine/threonine kinase that regulates critical mitotic events.

References

[1]. Takagi M, et al. In vivo antitumor activity of a novel sulfonamide, HMN-214, against human tumor xenografts in mice and the spectrum of cytotoxicity of its active metabolite, HMN-176. Invest New Drugs. 2003 Nov;21(4):387-99.

[2]. Garland LL, et al. A phase I pharmacokinetic study of HMN-214, a novel oral stilbene derivative with polo-like kinase-1-interacting properties, in patients with advanced solid tumors. Clin Cancer Res. 2006 Sep 1;12(17):5182-9.