Eletriptan hydrobromide

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Chemical Information

Product name：Eletriptan hydrobromide	Purity：98% min
CAS NO：177834-92-3	Solubility：Soluble in DMSO
Molecular Formula：C₂₂H₂₆N₂O₂S	Package：Package according to customer requirements
Molecular Weight：382.519	Storage：Store at -20℃

Quality control

COA

Remarks

Eletriptan Hydrobromide is a triptan with specific affinity for the 5-hydroxytriptamine1B/1D receptor. Eletriptan hydrobromide binds to and acts at serotonin 5-HT1B receptors located on intracranial blood vessels which leads to vasoconstriction. This drug may also exert its effects by binding to and activating 5-HT 1D receptors on sensory nerve endings in the trigeminal system, which results in the inhibition of pro-inflammatory neuropeptide release. Eletriptan hydrobromide is used to relieve pain or symptoms associated with migraine headaches.

Properties:
Appearance & Physical State: Tan solid
Melting Point: 169-171ºC
Boiling Point: 633.9ºC at 760 mmHg
Flash Point: 337.2ºC
Vapor Pressure: 1.58E-16mmHg at 25°C

References

[1]. Napier C, et al. Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur J Pharmacol, 1999, 368(2-3), 259-268.

[2]. MaassenVanDenBrink A, et al. Craniovascular selectivity of eletriptan and sumatriptan in human isolated blood vessels. Neurology, 2000, 55(10), 1524-1530.