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AZD7986, also known as INS 1007, is a second generation reversible covalent, potent and selective DPP1 inhibitor potentially for the treatment of chronic obstructive pulmonary disease (COPD) with predicted human PK properties suitable for once daily human dosing. AZD7986 showed pIC50 (DPPI) = 6.85. Good species crossover was seen for compound 30, with the DPP1 enzyme pIC50 values being determined to for mouse 7.6, rat 7.7, dog 7.8, and rabbit 7.8.