Product :
KB-R7943 mesylate
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Chemical Information
Product name:KB-R7943 mesylate |
Purity:98% min |
CAS NO:182004-65-5 |
Solubility:DMSO : ≥ 27 mg/mL (63.16 mM) |
Molecular Formula:C17H21N3O6S2 |
Package:Package according to customer requirements |
Molecular Weight:427.495 |
Storage:Store at -20℃ |
Remarks
KB-R7943 is a potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = 0.7 μM). KB-R7943 does not modify secondary pathology in the thalamus following focal cerebral stroke in rats. KB-R7943 blocks opening of the mitochondrial permeability transition pore. KB-R7943 restores endothelium-dependent relaxation induced by advanced glycosylation end products in rat aorta. KB-R7943 inhibits high glucose-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion.