TAS-102 Tipiracil hydrochloride

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Chemical Information

Product name：TAS-102 Tipiracil hydrochloride	Purity：98% min
CAS NO：183204-72-0	Solubility：DMSO : < 1 mg/mL; H2O : 50 mg/mL (179.13 mM)
Molecular Formula：C₉H₁₂Cl₂N₄O₂	Package：Package according to customer requirements
Molecular Weight：279.123	Storage：Store at -20℃

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Remarks

Tipiralacil, also known as TPI, is a thymidine phosphorylase inhibitor (TPI). Tipiracil is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials. TAS-102 consists of the cytotoxin Trifluridine and the thymidine phosphorylase inhibitor (TPI) tipiracil. Trifluridine is incorporated into DNA during DNA synthesis and inhibits tumor cell growth. Tipiracil protects trifluridine from being broken down when taken orally.

Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.

References

[1]. Peters GJ, et al. TAS-102: more than an antimetabolite. Lancet Oncol. 2012 Dec;13(12):e518-9.

[2]. Yoshino T, et al. TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Lancet Oncol. 2012 Oct;13(10):993-1001.