TAS-102 Tipiralacil

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Chemical Information

Product name：TAS-102 Tipiralacil	Purity：99% min
CAS NO：183204-74-2	Solubility：DMSO : 2.34 mg/mL (5.37 mM)
Molecular Formula：C₉H₁₂Cl₂N₄O₂	Package：Package according to customer requirements
Molecular Weight：242.662	Storage：Store at -20℃

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Remarks

Tipiralacil, also known as TPI, is a thymidine phosphorylase inhibitor (TPI). Tipiracil is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials. TAS-102 consists of the cytotoxin Trifluridine and the thymidine phosphorylase inhibitor (TPI) tipiracil. Trifluridine is incorporated into DNA during DNA synthesis and inhibits tumor cell growth. Tipiracil protects trifluridine from being broken down when taken orally.

References

[1]. Lee SJ, et al. Thymidine phosphorylase influences [(18)F]fluorothymidine uptake in cancer cells and patients with non-small cell lung cancer. Eur J Nucl Med Mol Imaging. 2014 Jul;41(7):1327-35.

[2]. Raedler LA. Lonsurf (Trifluridine plus Tipiracil): A New Oral Treatment Approved for Patients with Metastatic Colorectal Cancer. Am Health Drug Benefits. 2016 Mar;9(Spec Feature):97-100.