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Product :

OSI-420

OSI-420 183321-86-0
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Chemical Information
Product name：OSI-420 Purity：98% min
CAS NO：183321-86-0 Solubility：DMSO : ≥ 4.2 mg/mL (10.10 mM)
Molecular Formula：C21H21N3O4 Package：Package according to customer requirements
Molecular Weight：379.409 Storage：Store at -20℃
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Remarks

OSI-420 (CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.

Properties:
Density: 1.3g/cm3
Boiling Point: 572.8ºC at 760 mmHg
Flash Point: 300.2ºC
Refractive Index: 1.644
Vapor Pressure: 5.84E-14mmHg at 25°C

References
[1]. Meany HJ, et al. The plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite (OSI-420) after intravenous administration of erlotinib in non-human primates. Cancer Chemother Pharmacol. 2008, 62(3), 387-392.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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