AWD 131-138 Imepitoin

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：AWD 131-138 Imepitoin	Purity：98% min
CAS NO：188116-07-6	Solubility：DMSO : 12.5 mg/mL (44.69 mM)
Molecular Formula：C₁₃H₁₄ClN₃O₂	Package：Package according to customer requirements
Molecular Weight：279.722	Storage：Store at -20℃

Quality control

COA

Remarks

Imepitoin, also known as AWD 131-138, a novel antiepileptic drug for the treatment of canine idiopathic epilepsy. Imepitoin is a centrally acting anti-epileptic which crosses the blood brain barrier. It inhibits seizures via potentiation of the GABA a receptor-mediated inhibitory effects on the neurones. It also has weak calcium channel blocking effect which may contribute to its anticonvulsive properties.

References

[1]. Sigel E, et al. The antiepileptic drug AWD 131-138 stimulates different recombinant isoforms of the rat GABA(A) receptor through the benzodiazepine binding site. Neurosci Lett. 1998 Apr 3;245(2):85-8.

[2]. Yasar S, et al. Evaluation of the novel antiepileptic drug, AWD 131-138, for benzodiazepine-like discriminative stimulus and reinforcing effects in squirrel monkeys. Eur J Pharmacol. 2003 Apr 4;465(3):257-65.