Bazedoxifene

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Chemical Information

Product name：Bazedoxifene	Purity：98% min
CAS NO：198481-32-2	Solubility：Soluble in DMSO
Molecular Formula：₁₉₈₄₈₁-₃₂-₂	Package：Package according to customer requirements
Molecular Weight：470.603	Storage：Store at -20℃

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Remarks

Bazedoxifene is a third generation selective estrogen receptor modulator (SERM), developed by Pfizer following the completion of their takeover of Wyeth Pharmaceuticals. In late 2013, Pfizer received approval for bazedoxifene as part of the combination drug DUAVEE in the prevention (not treatment) of postmenopausal osteoporosis. Bazedoxifene is an indole-based ER ligand that binds to both ERα (IC50 = 26 nM) and ERβ (IC50 = 99 nM).

Related Products:

Bazedoxifene Acetate; Bazedoxifene intermediate(198479-63-9; 223251-25-0; 198480-21-6)

References

[1]. Lewis-Wambi JS, et al. The selective estrogen receptor modulator bazedoxifene inhibits hormone-independent breast cancer cell growth and down-regulates estrogen receptor α and cyclin D1. Mol Pharmacol. 2011 Oct;80(4):610-20.

[2]. Duggan ST, McKeage K. Bazedoxifene: a review of its use in the treatment of postmenopausal osteoporosis. Drugs. 2011 Nov 12;71(16):2193-212.

[3]. Lello S, Brandi ML, Minisola G et al. Bazedoxifene: literature data and clinical evidence. Clin Cases Miner Bone Metab. 2011 Sep;8(3):29-32.