MS023 dihydrochloride

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Chemical Information

Product name：MS023 dihydrochloride	Purity：98% min
CAS NO：1992047-64-9	Solubility：DMSO : ≥ 150 mg/mL (416.30 mM)
Molecular Formula：C₁₇H₂₇Cl₂N₃O	Package：Package according to customer requirements.
Molecular Weight：360.32	Storage：Store at -20°C

Quality control

Remarks

MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively.

References

[1]. Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11(3):772-81.

[2]. Yinghui Zhu, et al. Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia. Blood. 2019 Oct 10;134(15):1257-1268.