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GNE-6776

GNE-6776 2009273-60-1
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Chemical Information
Product name:GNE-6776 Purity:98%min
CAS NO:2009273-60-1 Solubility:Soluble in DMSO
Molecular Formula:C20H20N4O2 Package:Packaging according to customer requirements
Molecular Weight:348.41 Storage:Store at -20℃
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Remarks

Novel selective USP7 inhibitor, inducing tumour cell death, enhancing cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitorsGNE-6776 is a selective USP7 inhibitor that non-covalently targets USP7 (IC50 value at 1.34 μM) to attenuate ubiquitin binding, thus inhibiting deubiquitinase activity. It induces tumour cell death and enhances cytotoxicity with chemotherapeutic agents and targeted compounds including PIM kinase inhibitors.

References

1. Kategaya L, et al., 2017, Nature, 550(7677):534-538.

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